R -- Restricted
- DTS-HD Master Audio
- Blu-ray region A (North America, Central America, South America, Japan, Taiwan, North Korea, South Korea, Hong Kong, Southeast Asia)
- New Audio Commentary with Writer/Director James Gunn and Cast Members
- New Interview with James Gunn and Actor Greg Henry
- Audio Commentary with James Gunn and Actor Nathan Fillion
- Deleted Scenes
- Extended Scenes
- "Bringing Slither's Creatures to Life"
- Slithery set tour with Nathan Fillion
- The Making Of: "The Sick Minds and Slimy Days of Slither"
- Gag Reel
Number of Discs